2013.9－至今在电子科技大学临床医学院工作，任研究员、博士生导师

2012.3－至今在沙巴足球（中国）股份有限公司-官网·四川省人民医院工作，任研究员

2010.8－2012.3 在美国国家卫生研究院糖尿病消化病及肾病研究所从事博士后训练    

2006.5－2010.8在美国杰克森实验室从事博士后训练

2006年获德克萨斯大学奥斯汀分校（美国）细胞与分子生物学专业学士博士学位

2000年获中科院微生物研究所生物化学与分子生物学硕士学位

1997年获北京大学植物分子及发育生物学学生学位。

四川省神经科学学会                                      常务理事  

中华医学会医学遗传分会分子与基因组学组    组员

四川省医学会医学遗传学专业委员会              委员  

四川省实验动物学                                         常务理事  

作为项目负责人主持国家自然科学基金4项，国家重大研究计划973项目（课题骨干）1项、国家自然基金创新群体项目（课题骨干成员）1项，省科技厅科研项目5项，省卫健委科研课题1项，四川省人社厅课题1项，四川省人民医院涣花英才计划支持项目1项（200万元）。现有课题经费400余万元。

获2018年获四川省科技进步奖一等奖。

以第一作者或通讯作者发表学术论文46篇，其中SCI论文45篇，累积影响因子240分，北大核心期刊1篇。

以排名第一的身份申请发明专利19项，获得发明专利授权15项，国际发明专利1项。

研究方向

1. 基因敲除青光眼疾病模型和治疗研究

2. 视网膜疾病新基因功能和治疗研究

3. 血管发育和微血管病变分子机制研究

4. 非人灵长类疾病模型探索研究

近4年代表性研究论文：

1. Yeming Yang #, Ping Shuai #, Xiao Li, Kuanxiang Sun, Xiaoyan Jiang, Wenjing Liu, Weidong Le 5, Haisong Jiang*, Yuping Liu* and Xianjun Zhu*, Mettl14-mediated m6A modification is essential for visual function and retinal photoreceptor survival, BMC Biol. 2022 Jun 13;20(1):140. doi: 10.1186/s12915-022-01335-x. 影响因子7.3，中科院1区

2. Mu Yang#, Shujin Li#, Li Huang#, Rulian Zhao#, Erkuan Dai, Xiaoyan Jiang, Yunqi He, Jinglin Lu, Li Peng1, Wenjing Liu, Zhaotian Zhang, Dan Jiang, Yi Zhang, Zhilin Jiang, Yeming Yang, Peiquan Zhao, Xianjun Zhu*, Xiaoyan Ding*, Zhenglin Yang*，CTNND1 variants cause familial exudative vitreoretinopathy through the Wnt/cadherin axis. JCI Insight，2022 Jul 22;7(14):e158428. doi: 10.1172/jci.insight.158428. 影响因子9.484，中科院1区

3. Wenjing Liu, Xiaoyan Jiang, Xiao Li, Kuanxiang Sun, Yeming Yang, Mu Yang*, Shujin Li*, Xianjun Zhu*, LMBR1L regulates proliferation and migration of endothelial cells through Norrin/β-catenin signaling, Journal of Cell Science, 2022 Mar 15;135(6):jcs259468. doi: 10.1242/jcs.259468。影响因子5.235，中科院二区

4. Yeming Yang#, Jingshu Cai#, Xue Yang, Kaifang Wang, Kuanxiang Sun, Zhenglin Yang, Lin Zhang, Lu Yang, Chun Gu, Xiang Huang*, Ziyan Wang*, Xianjun Zhu*, Dysregulated m6A modification promotes lipogenesis and development of non-alcoholic fatty liver disease and hepatocellular carcinoma, Molecular Therapy, 2022 June, https://doi.org/10.1016/j.ymthe.2022.02.021.  影响因子12.91，中科院一区

5. Shujin Li#, Mu Yang#, Yunqi He#, Xiaoyan Jiang, Rulian Zhao, Wenjing Liu, Lulin Huang, Yi Shi, Xiao Li, Kuanxiang Sun, Yeming Yang, Periasamy Sundaresan, Peiquan Zhao, Zhenglin Yang*, Xianjun Zhu*. Variants in the Wnt co-receptor LRP6 are associated with familial exudative vitreoretinopathy, Journal of Genetics and Genomics. 2022 Jun;49(6):590-594. doi: 10.1016/j.jgg.2021.11.010.  

6. Yeming Yang, Kuanxiang Sun, Wenjing Liu, Xiao Li, Wanli Tian, Ping Shuai*, Xianjun Zhu*, The phosphatidylserine flippase β-subunit Tmem30a is essential for normal insulin maturation and secretion, Mol Ther. 2021 Apr 22:S1525-0016(21)00214-8. doi: 10.1016/j.ymthe.2021.04.026. 影响因子11.454，中科院一区

7. Xianjun Zhu #, Yang M#, Zhao P#, Li S#, Zhang L, Huang L, Huang Y, Fei P, Yang Y, Zhang S, Xu H, Yuan Y, Zhang X, Zhu X, Ma S, Hao F, Sundaresan P, Zhu W, Yang Z，Catenin alpha 1 mutations cause familial exudative vitreoretinopathy by overactivating Norrin/beta-catenin signaling. J Clin Invest. 2021 Jan 26:139869. doi: 10.1172/JCI139869. Online ahead of print. PMID: 33497368. SCI影响因子14.808, 中科院一区

8. Mu Yang#, Shujin Li#, Wenjing Liu#, Xiao Li, Yunqi He, Yeming Yang, Kuanxiang Sun, Lin Zhang, Wanli Tian, Zhenglin Yang*, Xianjun Zhu*, The ER membrane protein complex subunit Emc3 controls angiogenesis via the FZD4/WNT signaling axis, China Science Life Sciences, 2021 Jun 10. doi: 10.1007/s11427-021-1941-7. 影响因子6.2, 中科院一区

9. Yeming Yang#, Xiao Li#, Jieping Wang, Junkai Tan, Bernie Fitzmaurice, Patsy M Nishina, Kuanxiang Sun, Wanli Tian, Wenjing Liu, Xuyang Liu*, Bo Chang*, Xianjun Zhu*, A missense mutation in Pitx2 leads to early-onset glaucoma via NRF2-YAP1 axis, Cell Death Disease, 2021 Oct 29;12(11):1017. doi: 10.1038/s41419-021-04331-1. 影响因子9.6 , 中科院二区

10. Wenjing Liu#, Lei Peng#, Wanli Tian, Yi Li, Ping Zhang, Kuanxiang Sun, Yeming Yang, Xiao Li, Guisen Li* and Xianjun Zhu*, Loss of phosphatidylserine flippase beta-subunit Tmem30a in podocytes leads to albuminuria and glomerulosclerosis, Disease Model and Mechanism, 2021 Jun 1;14(6):dmm048777. doi: 10.1242/dmm.048777. 影响因子5.758，中科院二区

11. Junkai Tan#, Xiaoguang Zhang#, Danli Li, Guo Liu, Yun Wang, Daren Zhang, Xizhen Wang, Wenhong Tian, Xiaoyan Dong, Liang Zhou, Xianjun Zhu*, Xuyang Liu*, Ning Fan*, Mol Ther Methods Clin Dev. 2020 Apr 25;17:894-903. doi: 10.1016/j.omtm.2020.04.014. 并列通讯作者, SCI影响因子4.8，中科院二区

12. Huijuan Xu#, Chao Qu#, Li Gan, Kuanxiang Sun, Junkai Tan, Xuyang Liu, Zhilin Jiang, Wanli Tian, Wenjing Liu, Shanshan Zhang, Yeming Yang, Li Jiang, Xianjun Zhu*, Lin Zhang*, Deletion of the Impg2 Gene Causes the Degeneration of Rod and Cone Cells in Mice, Hum Mol Genet., 2020 Jun 27;29(10):1624-1634. doi: 10.1093/hmg/ddaa062. 通讯作者, SCI影响因子5.2，中科院二区

13. Liangyao Xiong#, Lin Zhang#, Yeming Yang, Na Li, Wenjia Lai, Fengchao Wang, Xianjun Zhu*, Tao Wang*, ER complex proteins are required for rhodopsin biosynthesis and photoreceptor survival in Drosophila and mice, Cell Death and Differentiation, 2020 Feb;27(2):646-661. doi: 10.1038/s41418-019-0378-6.  通讯作者, SCI影响因子15.0 , 中科院一区

14. Lin Zhang#, Xiang Zhang#, Huijuan Xu, Lulin Huang, Shanshan Zhang, Wenjing Liu, Yeming Yang, Ping Fei, Shujin Li, Mu Yang, Peiquan Zhao*, Xianjun Zhu*, Zhenglin Yang*, Exome sequencing revealed Notch ligand JAG1 as a novel candidate gene for familial exudative vitreoretinopathy, Genet Med. 2020 Jan;22(1):77-84. doi: 10.1038/s41436-019-0571-5.通讯作者, SCI影响因子8.6 , 中科院一区

15. Yeming Yang, Kuanxiang Sun, Wenjing Liu, Lin Zhang, Kun Peng, Shanshan Zhang, Shujin Li, Mu Yang, Zhilin Jiang, Fang Lu, Xianjun Zhu*, Disruption of Tmem30a results in cerebellar ataxia and degeneration of Purkinje cells. Cell Death & Disease, 2018 Sep 5; 9(9):899. doi: 10.1038/s41419-018-0938-6. 通讯作者, SCI影响因子5.6 , 中科院二区

16. Lin Zhang#, Zixi Sun#, Peiquan Zhao#, Lulin Huang, Mingchun Xu, Yeming Yang, Xue Chen, Fang Lu, Xiang Zhang, Hui Wang, Shanshan Zhang, Wenjing Liu, Zhilin Jiang, Shi Ma, Rui Chen, Chen Zhao, Zhenglin Yang*, Ruifang Sui*, Xianjun Zhu*, Whole exome sequencing revealed HKDC1 as a candidate gene associated with autosomal-recessive retinitis pigmentosa, Human Molecular Genetics, ddy281, https://doi.org/10.1093/hmg/ddy281, Published: 31 July 2018, 通讯作者, SCI影响因子5.2；中科院二区

2020年度四川省科研系统先进个人

2018年获得四川省卫计委学术带头人称号

2019年获聘四川省卫生健康领军人才

四川省海外高层次人才“百人计划”（2012）